abstract |
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formular I, II, III and IV have the structure: <IMAGE> (I) <IMAGE> (II)X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification. |