| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db72781338b7c026a276f17294405c4f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55 |
| filingDate |
2020-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2023-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7539ca4a7dba7bbcb5e309c86a78730
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c43ac289a4805d0088c01fbfbabc974
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a3ce923d0765c331f4e97ea6d532646
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e42a1a0e96e665420f77ce5b5b3bdc7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e9d4574e515f716547623283c1ab42e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac3f52312afa5fa36e3a878c27eff08e |
| publicationDate |
2023-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11554171-B2 |
| titleOfInvention |
Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| abstract |
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides. |
| priorityDate |
2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |