| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db72781338b7c026a276f17294405c4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a14bc51d553ebeb643965a19fcf6222 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 |
| filingDate |
2016-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_129d570bc63c674c04f92128351ff557
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97b88b3d115efeb478834496dfcdf3f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1e9ea7e4320bdc7fcaf053695214b40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2cffa4208e2de63108f7d343eb355b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62f5bd26a68cfab77539058fb7c6363a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8d5b7ea7c73c066f5ce96e0f8ca7c0 |
| publicationDate |
2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10772962-B2 |
| titleOfInvention |
Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| abstract |
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023034411-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11161842-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11291732-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11667628-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11642413-B2 |
| priorityDate |
2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |