http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10689640-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee6b113b79349a731bce050dff0b2031 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate | 2016-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74eb6d237f194ca22f8d4aea5274147d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f68b9cce0f7cc5b15175d11bd5a225dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_695ed888d76ab557ade9a4f0692f0d95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c06d86749989d3f48e0283f0ff4aa335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea09fbf7a225bd7cc561ce2cd4d5888d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dccccb621e268abfe82d4c74a56129fa |
| publicationDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10689640-B2 |
| titleOfInvention | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| abstract | The present invention provides an array for rapidly identifying a host cell population capable of producing a heterologous recombinant protein with improved yield and/or quality. The array comprises one or more host cell populations that have been genetically modified to increase the expression of one or more target genes involved in protein production, decrease the expression of one or more target genes involved in protein degradation, or both. One or more of the strains in the array may express the heterologous recombinant protein of interest in a periplasm compartment or may secrete the heterologous recombinant protein extracellularly through an outer cell wall. The strain arrays are useful for screening for improved expression of any protein of interest including therapeutic proteins, hormones, growth factors, extracellular receptors or ligands, proteases, kinases, blood proteins, chemokines, cytokines, antibodies and the like. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11377661-B2 |
| priorityDate | 2007-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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