| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_06c87200cf96acdabeae38cd1101927d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2535-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2523-125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6874
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6881
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6874
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6881
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B30-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B30-00 |
| filingDate |
2014-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c0af43c33e974bd440c2d811fe52f40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d201b9ad7bb6d97dc3a6d73551c6abb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b70f2a26be1329344e80a19e58fdffb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa13ccb81450fcb31dc9b075eeb3b6c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3b3fe8122ee754726b32e0dc7c402d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7a6c0a641956cf1a091662b1073e620 |
| publicationDate |
2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10392666-B2 |
| titleOfInvention |
Non-invasive determination of methylome of tumor from plasma |
| abstract |
Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11410750-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11685958-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11530453-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11274347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10706957-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11725251-B2 |
| priorityDate |
2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |