| abstract |
An active-source-pixel, integrated device capable of performing biomolecule detection and / or analysis, such as single-molecule nucleic acid sequence analysis, is described. The active pixel of the integrated device includes a sample well to which a sample to be analyzed can be diffused, an excitation source to provide excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may include two or more segments attached to the sample or creating a set of signals to be analyzed to identify and identify tags associated with the sample. The tag distinction may be spectral and / or time based. Identification of the tags can be used to detect, analyze, and / or sequence the biomolecule. |