| abstract |
The present invention relates to a novel method for producing safe and improved productivity in the synthesis of propiberine hydrochloride (Formula 1), a treatment for incontinence,n n n More specifically, the substitution using 4-hydroxy-1-methylpiperidine and 1-propanol using 2-chloro-2,2-diphenylacetyl chloride (Aldrich, C3928-8), which is a known substance, as a starting material It can be synthesized in only one step through the reaction and provides a method for producing propiberine hydrochloride (Formula 1), characterized in that the purification by recrystallization method, the yield is higher than the conventional method, the process is simple, the production stage is low and simple and It is characterized by providing a high-purity propiberine hydrochloride (Formula 1) quickly.n n n [Formula 1] |