| abstract |
The present invention is a form in which a hydrophilic material and a hydrophobic material are conjugated to both ends of a double-stranded oligonucleotide by a simple covalent bond or a linker-mediated covalent bond in order to efficiently deliver androgen receptor-specific oligonucleotide into cells. A double-stranded oligonucleotide structure having a structure, nanoparticles that can be produced by self-assembly of the double-stranded oligonucleotide structures in an aqueous solution by hydrophobic interaction, and a composition for preventing hair loss or growing hair containing the double-stranded oligonucleotide structure Thus, the double-stranded oligonucleotide structure containing the androgen receptor-specific oligonucleotide according to the present invention and the composition for preventing hair loss or growing hair containing the same as an active ingredient can suppress the expression of the androgen receptor with high efficiency without side effects, resulting in hair loss , In particular, it can achieve excellent effects in preventing androgenetic alopecia, alopecia areata, and telogen effluvium and inducing hair growth. |