| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6935
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate |
2014-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-101862349-B1 |
| titleOfInvention |
Improved nanoparticle type oligonucleotide structure having high efficiency and method for preparing same |
| abstract |
The present invention relates to an oligonucleotide construct and a method for producing the oligonucleotide. More particularly, the present invention relates to an oligonucleotide construct in which a polymer compound is covalently linked to an oligonucleotide for enhancing in vivo stability of the oligonucleotide and improving cell transfer efficiency, And a manufacturing method thereof. The improvement of the oligonucleotide structure to the homogenous substance solves the problem of the verification of the material due to the polydispersity property which occurs when the hydrophilic substance bound to the oligonucleotide is a synthetic polymer, And the size of the double helix oligo RNA structure can be precisely controlled by controlling the number of repetitions of the hydrophilic material block so that the synthesis of the optimized oligonucleotide structure does not inhibit the function of regulating the gene expression of the oligonucleotide, Since the oligonucleotide can be delivered into the cells at a dose, it can be used not only as a therapeutic tool in cancer and infectious diseases, but also as a new type of oligonucleotide delivery system. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022182188-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102473989-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022191567-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20220126659-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20220121743-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200064233-A |
| priorityDate |
2013-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |