| abstract |
NEW MATERIAL:The titled compound of formula I (R 1 is H, lower alkyl, lower alkenyl, etc.; R 2 is H, lower alkyl, etc.; Z is H, etc.). n EXAMPLE: 6-[3-(1-Ethyltetrazol-5-yl)propoxy]-3,4-dihydrocarbostyril. n USE: Useful as a remedy for thrombosis, a cerebral circulation improving agent, antiphlogistic agent, antiulcer agent, hypotensive agent, anti-asthmatic agent and phosphodiesterase inhibiting agent. Prolonged activity, low toxicity and low side effects. n PROCESS: The compound of formula I is prepared by reacting a hydroxycarbostyril of formula II (R 2 ' is H, lower alkyl, or hydroxy; Z' is H or hydroxy, provided that one of Z' and R 2 ' is hydroxy and both Z' and R 2 ' are not H at the same time) with a tetrazole derivative of formula III (X is halogen) in the presence of a basic compound (e.g. sodium hydroxide) as a dehydrohalogenating agent. n COPYRIGHT: (C)1981,JPO&Japio |