| abstract |
The present invention relates to a compound of formula (I): [Chemical 1] A tetrazolylalkoxydihydrocarbostyryl compound wherein R is cycloalkyl, A is lower alkylene, and the bond between the 3- and 4-positions of the carbostyryl ring is a single or double bond; Or a novel PTEN inhibitor containing a salt thereof as an active ingredient or a novel opener of a K + channel activated by large conductive Ca 2+ (Maxi-K channel), which is a normal cell, brain cell, heart It is useful as a drug that promotes the survival of cells and skin, and further inhibits Gram-negative sepsis and cell migration and cell invasion by inhibiting PTEN, and also a therapeutic agent for nervous system disorders, such as anticonvulsants, neuroprotective agents , Regional brain edema and neuromotor disorders, cognitive impairment, traumatic brain injury, Parkinson's disease, epilepsy, migraine, and Alzha It is useful as a therapeutic agent such as a mer's disease. |