| abstract |
NEW MATERIAL:5-Fluorouracil derivatives of formula I (R is aliphatic hydrocarbyl with bridged ring, sustituted lower alkyl). n EXAMPLE: 1-[N-(1-adamantylmethyl)carbamoyl]5-fluorouracil. n USE: An antitumorigenic agent. n PREPARATION: 5-Fluorouracil of formula I is made to react with an isocyanate of formula III (Ra is aliphatic hydrocarbyl with bridged ring, substituted lower alkyl) in a solvent as benzene or DMSO, under anhydrous conditions at room temperature or with heat to produce the objective compound of formula Ia. n COPYRIGHT: (C)1980,JPO&Japio |