http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5785374-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 1980-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54af6e8db59d6e04a3ed0c29582622ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c01ebfde04f3050922528eb2d4777f7 |
| publicationDate | 1982-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5785374-A |
| titleOfInvention | 5-fluorouracil derivative and its preparation |
| abstract | NEW MATERIAL:A 5-fluorouracil derivative expressed by formula I(R is 5- ethylenedioxyhexyl, 5-oxohexyl or 5-hydroxyhexyl). n EXAMPLE: 1-(5-Ethylene dioxyhexylcarbamoyl)-5-fluorouracil. n USE: A carcinostatic agent. n PROCESS: 5-Oxocapronitrile is reacted with ethylene glycol in the presence of an acidic catalyst, e.g. p-toluenesulfonic acid, to form 5-ethylenedioxycapronitrile expressed by formula II, which is then catalytically reduced with lithium aluminum hydride or Raney nickel to give 5-ethylenedioxyhexylamine. The resultant compound is then reacted with 1-chlorocarbonyl-5-fluorouracil to afford the compound expressed by formula I(R is 5-ethylenedioxyhexyl). n COPYRIGHT: (C)1982,JPO&Japio |
| priorityDate | 1980-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.