| abstract |
The present invention provides compounds of formula (I): (wherein R1 and R2 represent hydrogen or a deuterium atom; R3 represents a hydrogen atom or a —COOH, —OH or —OPO (OH) 2 group; Represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or an —OH group; (wherein at least one of R3 and R5 is different from a hydrogen atom; R3 represents —COOH, —OH or —OPO (OH ) When it represents two groups, the result R5 represents a hydrogen atom; when R5 represents an —OH group, the result R3 and R4 represent a hydrogen atom); R6 is optionally substituted phenyl, Selected from heteroaryl, cycloalkyl or heterocycloalkyl groups). The present invention also relates to the preparation of compounds of formula (I) and therapeutic use as inhibitors and degradants of estrogen receptors that are particularly useful in the treatment of cancer. [Chemical 1] |