| abstract |
The present invention relates to triphenylethylene derivatives, such as 3- (4- [6- (3-methoxy-phenyl) -8,9-dihydro-7H-benzocycloheptene-5, as selective estrogen receptor modulators. -Yl] -phenyl) -acrylic acid. The invention also provides for the treatment of estrogen-stimulated diseases in mammals, including breast cancer, uterine cancer, ovarian cancer, prostate cancer, colon cancer, osteoporosis, cardiovascular disease, and benign proliferative diseases. Also provided are methods for the prevention, as well as pharmaceutical compositions of the compounds of the invention. |