| abstract |
Provided are novel small molecule E3 ubiquitin ligase protein binding ligand compounds that have utility in proteolysis targeted chimeras (PROTACs), processes for their preparation, and use in medicine. In particular, PROTACs that bind to proteins within bromo- and extra-terminal (BET) family proteins are provided, and in particular PROTACs selectively induce degradation of BRD4 protein within bromodomine of the BET family of proteins Novel small molecule E3 ubiquitin ligase protein binding ligand compounds are included. |