| abstract |
The present invention relates to bifunctional compounds useful as modulators of targeted ubiquitination, particularly as inhibitors of various polypeptides and other proteins, where these polypeptides and proteins are degraded and degraded by the bifunctional compounds of the present invention. / Or otherwise inhibited. In particular, the present invention provides a VHL ligand that binds to a ubiquitin ligase at one end and a moiety that binds to a target protein at the other end so that the target protein is placed in close proximity to the ubiquitin ligase to degrade (and inhibit) that protein. ) Is intended to include compounds. The present invention exhibits a wide range of pharmacological activities associated with the compounds of the present invention consistent with degradation / inhibition of the target polypeptide. |