| abstract |
The present invention relates to compositions and methods for controlling the specificity and activity of immune effector cells for use in immunotherapy. In certain embodiments, the present invention provides a type of chimeric antigen receptor (CAR), where CAR is a CAR design that includes components naturally found in natural killer (NK) cells, “NKR- Name it CAR. In certain embodiments, NK receptors include, but are not limited to, the naturally occurring activating and inhibitory receptors of NK cells known as killer cell immunoglobulin-like receptors (KIRs). |