| abstract |
Compounds of general formula I that modulate pyruvate kinase: And compositions comprising a compound of general formula I are described herein. Also described herein are methods of using compounds that modulate pyruvate kinase in the treatment of disease. Also, pharmaceutical compositions comprising the compounds provided herein, and diseases and conditions related to pyruvate kinase function, eg, PKR function, and / or PKM2 function (eg, cancer, diabetes, obesity, autoimmune disorders) And the use of such compositions in methods of treating benign prostatic hyperplasia (including BPH). |