| abstract |
The use of substituted amides to modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β HSD1) and the use of these compounds as pharmaceutical compositions has been described. A new class of substituted amides, their use in therapy, pharmaceutical compositions containing the compounds, and their use in the manufacture of a medicament are described. This compound is a modulator of 11βHSD1 activity, and more specifically, is an inhibitor of 11βHSD1 activity, and it is desirable to reduce the intracellular concentration of active glucocorticoids. And / or may be useful in prevention. |