| abstract |
The present invention relates to compounds of the following formula that are useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment of various diseases, conditions or diseases such as cancer. The compounds and compositions provided by the present invention also provide for the study of DNA-PK in biological and pathological phenomena, the study of intracellular signaling pathways mediated by such kinases, and new kinase inhibitors Useful for comparative evaluation. |