| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate |
2017-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2019-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2019529475-A |
| titleOfInvention |
Method for treating cancer using a combination of a DNA damaging agent and a DNA-PK inhibitor |
| abstract |
A method of treating a proliferative disorder in a subject by administering a DNA damaging agent and administering the DNA-PK inhibitor to the subject between about 8 hours and about 48 hours later. It is described in the book. Exemplary DNA-PK inhibitors have the formula (BI) And by a pharmaceutically acceptable salt thereof, wherein R 1 , Q, ring A and ring B are as defined herein. The present invention is unexpected that a DNA-dependent protein kinase (DNA-PK) inhibitor administered between about 8 hours and about 48 hours after a DNA damaging agent is particularly effective in the treatment of proliferative diseases. Based at least in part on the discovery. |
| priorityDate |
2016-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |