| abstract |
Described herein are compositions comprising a compound and a compound that modulates pyruvate kinase M2 (PKM2). Also described herein are methods of using compounds that modulate PKM2 in cancer therapy. In other embodiments, the endogenous ability of the patient's cells to modulate (eg, increase or decrease) PKM2 activity and / or glycolysis levels in a patient in need (eg, downregulate PKM2). Is provided. This method comprises the steps of modulating (eg, increasing or decreasing) the level of PKM2 activity and / or glycolysis in a patient by administering to the patient in need thereof an effective amount of a compound described herein. Including. In certain embodiments, the method comprises identifying or selecting a patient that is likely to respond to PKM2 activation. |