abstract |
Disclosed are pyruvate kinase M2 activators, compounds of formula (I), including compounds of formula (II), useful for the treatment of many diseases (eg, cancer) that can treat the activation of PKM2. A 1 -NR-LA 2 (I) (Wherein, A 1, A 2, L , R, R 1 ~R 3, X 1 ~X 3, k, n and m are as defined in the specification.) |