| abstract |
Disclosed are a chondroitinase gene variant, a polypeptide and protein derived therefrom, and a method for promoting neurological functional recovery after a disorder or disease of the central nervous system ("CNS"). Biologically active proteoglycan degrading polypeptide, preferably a chondroitinase degrading enzyme protein variant (eg, chondroitin degrading enzyme ABC type I, chondroitin degrading enzyme ABC type II, chondroitin degrading enzyme AC, chondroitin degrading enzyme B) Its use in a method of promoting the modulation and deficiency of the drug, the diffusion of therapeutic components into the tissue, its use for central nervous system ("CNS") disorders or neurological function recovery after disease. [Selection] Figure 7 |