| abstract |
(57) [Summary]nDisclosed are human VEGF-2 polypeptides, biologically active and diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF-2 polypeptides. Is done. Also provided are procedures for producing such polypeptides by recombinant techniques, as well as antibodies and antagonists to such polypeptides. Such polypeptides and polynucleotides can be used therapeutically to stimulate wound healing and to repair vascular tissue. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thereby tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis. |