abstract |
The present invention provides compounds of formula (I) and tautomers, isomers and esters of said compounds, and pharmaceutically acceptable salts, solvates and prodrugs of said compounds, wherein R , R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 and n are each independently selected; As defined herein. Compositions comprising such compounds are also provided. The compounds of the present invention are effective as inhibitors of HCV and are effective alone or in combination with other therapeutic agents in the treatment or prevention of diseases or disorders such as viral infections and virus-related disorders. |