http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-731956-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2dbb2d7ecbd600cf89fbdd230f4a466c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 |
| filingDate | 1952-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1955-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-731956-A |
| titleOfInvention | New pyrimidine compounds |
| abstract | The invention comprises compounds, having chemotherapeutic properties, of the general formula <FORM:0731956/IV (b)/1> (where R is an aliphatic radical containing 1 to 6 carbon atoms or a cycloalkyl or aralkyl radical and is preferably an alkyl group of 1 to 4 carbon atoms) and their salts. They may be prepared by reacting 2-amino-4-chloro - 5 - (41 - chlorophenyl) - 6 - ethyl pyrimidine or its 2-acetylamino derivative with an amine of the formula RNH2 or with a salt of such an amine. When using an amine as such, the reactants are heated to above 100 DEG C., optionally in the presence of a solvent such as ethanol, and when using a lower aliphatic amine, under superatmospheric pressure. If the amine salt is used, the reaction proceeds above 150 DEG C. in the absence of a solvent and in all cases under normal pressure. In the example, compounds are described of the above formula where R is methyl, ethyl, n-propyl, isopropyl, n-butyl, n-pentyl, n-hexyl, 21-butyl, 31-pentyl, 31-methyl-butyl, cyclohexyl, allyl and benzyl. Specification 730,499 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8697694-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2009282567-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011318305-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012500278-A |
| priorityDate | 1951-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.