abstract |
The present invention provides novel thiazoles possessing 3-pyridyl or 4-isoquinolinyl substituents, and pharmaceutical compositions thereof. The present invention also provides methods of using the compounds of the present invention and their pharmaceutical compositions as inhibitors of lyases, such as the 17α-hydroxylase-C17,20 enzyme. The present invention further provides a method of treating cancer in a subject, comprising administering to the subject a compound of the present invention or a pharmaceutical composition thereof. The cancer can be, for example, prostate cancer or breast cancer. |