| abstract |
Cell-penetrating peptides useful for targeting therapeutic compounds to selected mammalian tissues, methods of identification thereof, methods of forming conjugate compounds containing such peptides, and conjugates formed thereby Is disclosed. The cell penetrating peptide is 8-30 amino acid residues in length and consists of a partial sequence selected from the group consisting of RXR, RX, RB, and RBR, wherein R is arginine and B is a β- alanine, and each X is independently -C (O) - (CHR 1) a n -NH-, wherein n is 4 to 6, R 1 each R 1 is methyl Is independently H or methyl, so that there are at most two. In one embodiment, X is a 6-aminohexanoic acid residue. |