| abstract |
Provided herein are compositions and methods that increase the transport of biologically active compounds across biological membranes and across animal epithelial or endothelial tissues into the tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ) n Z, (ZY) n Z, (ZYY) n Z and (ZYYY) n Z. The subscript “Z” is L-arginine or D-arginine, and the subscript “Y” is an amino acid that does not contain an amidino or guanidino moiety. The subscript “n” is an integer of 2 to 10. This method for increasing transport includes administering the foregoing composition. |