abstract |
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, esters and prodrugs thereof, which are inhibitors of factor Xa. The present invention relates to intermediates used to make such compounds, pharmaceutical compositions containing such compounds, methods for preventing or treating a number of conditions characterized by undesirable thrombosis, and blood samples It also relates to a method of inhibiting coagulation. The invention also includes a mammal characterized by undesirable thrombosis comprising the step of administering to the mammal a purified form of the compound, chemical intermediate, pharmaceutical composition, and a therapeutically effective amount of a compound of the invention. Further provided is a method of preventing or treating a disease state in |