| abstract |
The present invention provides a substituted oxopyridine derivative represented by the following formula: wherein R 1 is a group of the following formula, * is a bonding site to the oxopyridine ring, R 6 is bromine, chlorine, fluorine, methyl, Difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy, R 7 is bromine, chlorine, fluorine, cyano, nitro, hydroxyl, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, tri Fluoromethoxy, ethynyl, 3,3,3-trifluoroprop-1-in-1-yl or cyclopropyl], and methods for their preparation, as well as diseases, particularly cardiovascular diseases, preferably thrombus or thromboembolism For the treatment and / or prevention of diseases and edema, as well as ophthalmic disorders It relates to their use for the manufacture of medicaments. [Chemical 1] |