| abstract |
Structural formula (I): Compounds having a androgen receptor (AR) tissue-selective modulator. Said compounds are used in strengthening weakened muscle tone, as well as osteoporosis, osteopenia, steroidal osteoporosis, periodontal disease, fractures, bone damage after bone reconstruction, skeletal muscle loss, weakness, skin Aging, male hypogonadism, female postmenopausal syndrome, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, irreproducible anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV Wasting, prostate cancer, prostatic hypertrophy (BPH), abdominal steatosis, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophy, cognitive decline, sexual dysfunction, sleep apnea, depression, early menopause and Useful alone or in combination with other active agents in the treatment of conditions resulting from androgen deficiency, including autoimmune diseases, or can be ameliorated by androgen administration That. |