| abstract |
The compounds of structural formula I are androgen receptor (AR) modulators in a tissue selective manner. These compounds, alone or in combination with other active agents, increase weak muscle tone, as well as osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, fractures, bone damage after bone reconstruction, sarcopenia , Weakening, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammation Osteoarthritis and joint repair, HIV pancreatic, prostate cancer, benign prostatic hypertrophy (BPH), abdominal obesity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophy, cognitive decline, sexual dysfunction, sleep Conditions that result from and can be ameliorated by androgen deficiency, including apnea, depression, premature ovarian failure, and autoimmune disease It is useful to care. |