| abstract |
The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: [Chemical 1] In which R, R 1 , R 2 , R 3 and R 4 are as defined herein. Moreover, this invention relates to the manufacturing method of these compounds. The compounds of the present invention are inhibitors of poly (adenosine 5′-diphosphate ribose) polymerase (PARP), and thus the treatment and / or prevention of various diseases, particularly those associated with the central nervous system and cardiovascular disorders. It is useful as a pharmaceutical product. |