| abstract |
The present invention provides a 4-aryl-5-hydroxyisoquinolinone derivative having excellent PARP inhibitory activity, an addition salt thereof, a method for producing the same, and a pharmaceutical composition thereof. SOLUTION: General formula (1) [Wherein R 1 represents a hydrogen atom or a halogen atom, and the ring Ar is represented by the general formula (2) , A naphthyl group which may have a substituent, or a 5- or 6-membered heterocyclic ring which may have a substituent and a condensed ring thereof]]. Derivatives and their addition salts. [Selection diagram] None |