| abstract |
The present invention provides a compound of formula (I), (II) represented by and (III), wherein R1, R2, R3, R4, Y, W 1, W 2, L, A, Alk, Cyc, Ar, Het 1 , Het 2 , HaI and n relate to compounds having the meanings stated in claim 1 and / or their physiologically innocuous salts, tautomers and stereoisomers, and mixtures thereof in all proportions. The compounds of formula (I) can be used to inhibit serine-threonine protein kinases and also to sensitize cancer cells to anticancer substances and / or ionizing radiation. The invention also relates to the use of a compound of formula (I) in the prevention, therapy or suppression of progression of cancer, tumor, metastasis or angiogenesis disorders in combination with radiation therapy and / or anticancer agents. . The present invention further relates to a process for producing a compound represented by formula (I), comprising reacting a compound represented by formula (II) and (III) and optionally reacting a compound represented by formula (I) It relates to said process by converting a base or acid into one of their salts. |