abstract |
A novel denaturant stable, protease resistant, homo-oligomeric protein, referred to as a stable protein (SP) with chaperone-like activity. SP production and purification methods. A nucleic acid encoding SP. A method for isolating a nucleic acid encoding SP. An antibody that recognizes SP. Use of SP to stabilize, refold, repair, and prevent aggregation and disaggregation of macromolecules such as proteins. A fusion protein comprising SP. A nucleic acid construct encoding a fusion protein. Their use in various methods and applications. |