| abstract |
Disclosed are heterocyclic-substituted compounds of formula (I) or pharmaceutically acceptable salts thereof. Where: Z is — (CH 2 ) n —; (a); (b) where R 10 is absent; or (c) where R 3 is absent. A single dotted line represents any double bond; a double dotted line represents any single bond; n is 0 to 2; Het is an optionally substituted monocyclic; A bicyclic or tricyclic heterocyclic aromatic group; B is — (CH 2 ) n3 — (where n3 is 0 to 5), —CH 2 —O—, — CH 2 S—, —CH 2 —NR 6 —, —C (O) NR 6 —, —NR 6 C (O) —, (d), optionally substituted alkenyl, or optionally substituted alkynyl There; X, when the two dotted lines represents a single bond, -O- or -NR 6 - or where X, if this bond is not present, H, -OH Properly is -NHR 20. |