| abstract |
Disclosed are compounds represented by the following structural formulas, and pharmaceutically acceptable salts and solvates thereof, wherein a singlet between the ring carbon to which R 10 is attached and the ring carbon to which R 34 is attached: The dotted line represents either a single bond or a double bond; the double dotted line between X and the carbon to which Y is bonded represents either a single bond or the absence of a bond; When the heavy dotted line represents a single bond, it is —O— or —NR 6 —; X represents H, —OH or NHR 20 when the double dotted line represents the absence of a bond; and other parameters Is as defined herein. Also disclosed are pharmaceutical compositions comprising the above compounds and combinations comprising the above compounds, and their use as binding agents for thrombin receptor antagonists and cannabinoid receptors. |