| abstract |
Heterocyclic substituted tricyclic compounds of formula (I), or pharmaceutically acceptable salts or solvates, isomers or racemic mixtures of the compounds wherein Represents any double bond and the dotted line is optionally bonded or unbonded, resulting in a double bond or a single bond, as allowed by valence requirements, where A, B, G, M, X, J, n, Het, R 3 , R 10 , R 11 , R 32 and R 33 are defined herein and the remaining substituents are as defined herein. And pharmaceutical compositions containing them, and administration of the compounds to produce thrombosis, atherosclerosis, restenosis, hypertension, A method of treating diseases associated with angina, arrhythmia, heart failure and cancer. Combination therapy with other cardiovascular agents is also claimed. |