| abstract |
(57) [Summary]nDerivatives of the antitumor agent are prepared. The derivative may form a covalent bond with one or more blood components, especially mobile blood components. Provided is the use of a composition for the manufacture of a medicament for use in the treatment of cancer, the composition comprising a derivative of taxol and its analogs, wherein the derivative comprises an amino group in a blood component, It includes a reactive group that reacts with a hydroxyl or thiol group to form a stable covalent bond, wherein the reactive group is selected from N-hydroxysuccinimide, N-hydroxy-sulfosuccinimide and maleimide groups. |