| abstract |
PURPOSE: To obtain an antitumor agent having high affinity to cancer cell and remaining in cancer tissue for a long period to keep the antitumor activity, by bonding an antitumor substance to a human-originated (modified) albumin and using the obtained compound as an active component. n CONSTITUTION: A human-originated albumin or a modified albumin produced by the partial acetylation or succinylation of albumin is bonded with an antitumor substance directly or through a spacer such as dextran or polyglutamic acid. When the antitumor substance has e.g., a free amino group, said amino group is condensed with the amino group of albumin using succinimidyl pyridyl dithiopropionate, etc., or with the carboxyl group of albumin using carbodiimide. n COPYRIGHT: (C)1989,JPO&Japio |