| abstract |
PURPOSE:To obtain a selective chemotherapeutant having a maleimide residue on the surface of a liposome containing a drug such as an anticancer agent, an antibody not binding through a thiol group and a polyalkylene glycol residue. CONSTITUTION:A liposome having a malemide group is reacted with a protein to which a thiol group is provided and the residual maleimde group is reacted with a compound containing a polyalkylene glycol part to which a thiol group is bound to provide a drug (preferably an antiulcer agent)-containing antibody- bound liposome improved in intake in a membrane system. An antibody is preferably used as the protein and dipalmitoyphosphatidyl choline, etc., is preferably used as the liposome. The liposome obtained by the above-mentioned method can suppress nonspecific intake in the membrane system of liver, spleen, etc., and is useful as a selective chemotherapeutant, especially medicine for cancer. |