| abstract |
(57) [Summary]nA bilayer controlled release delivery system for a highly water-soluble drug such as an antidiabetic drug metformin HCl salt, which provides a dosage form that prolongs gastric retention, (1) a drug having high water solubility, and One or more hydrophilic polymers, one or more hydrophobic polymers and / or one or more hydrophobic substances such as one or more waxes, fatty alcohols and / or fatty acid esters And (2) the granules of the inner solid particle layer are embedded and dispersed throughout, and the outer solid continuous layer is formed of one or more hydrophilic particles. Water-soluble polymer, one or more hydrophobic polymers and / or one or more waxes, one or more waxes, such as fatty alcohols and / or fatty acid esters. Including a hydrophobic material, the bilayer controlled release delivery system may be compressed into tablets or filled into capsules. Also provided are methods for forming the described bilayer controlled release delivery system and methods of using the bilayer controlled release delivery system for the treatment of diabetes. |