| abstract |
(57) Summary Multivesicular liposomes are prepared on a commercial scale by combining a first w / o emulsion with a second aqueous solution to form a w / o / w emulsion using a static mixer. The solvent is removed from the resulting emulsion to form a multivesicular liposome-containing composition. Further optional process steps include primary filtration and secondary cross-flow filtration. The product produced according to the method of the present invention may be produced through a series of aseptic steps. |