| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a186fb3ec97c01577f074464094d981c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_692dc75829481c48c017b52f352e2bad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_459fec1b63a916fdecd5f7780fa322f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18fec701dcbe229beddb6965d0781d7e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate |
2012-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adf10be5da9c06156473dc0cb16d0696
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bd7bb9dca9e18aab9feb08fc9833cc5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79a29438d385039b6102c9f61f262371 |
| publicationDate |
2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012133121-A1 |
| titleOfInvention |
Long-lasting controlled-release liposome composition and method for producing same |
| abstract |
The invention provides a liposome composition, which is obtained by mixing a water-miscible organic solution in which a phospholipid and cholesterol are contained at a total concentration of 100 to 200 w/v% in a water-miscible organic solvent with a first aqueous phase solution in an amount of 3/1 to 12/1 in terms of volume ratio to the water-miscible organic solution, thereby obtaining an emulsion in which the total concentration of the phospholipid and cholesterol in the resulting mixed phase is 15 to 50 w/v%, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution, wherein an ion gradient is formed between an aqueous phase in an internal region of a liposome membrane, comprising the first aqueous phase solution and an aqueous phase in an external region of the liposome membrane, comprising the second aqueous phase solution, and a drug can be introduced in a high encapsulation amount. The invention also provides a liposome preparation which has long-lasting controlled-release properties while maintaining a clinically sufficient effective concentration and is suitable for subcutaneous administration and so on. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014046191-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9724300-B2 |
| priorityDate |
2011-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |