| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-05 |
| filingDate |
2011-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_442e28e97ee9bc00475b0a57c3088ad2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bff3a07a9e842aa30d6f2750a5e987a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4710778bb327dacda086abdb16695d1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33a3a2629296ca8ffddd361f6b35f26f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89302a99c85c2611d351beb575f2f06f |
| publicationDate |
2013-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2495341-A |
| titleOfInvention |
Fermentation medium for increased yield of Corynebacterium diphtheriae toxin, and uses of the toxin. |
| abstract |
The present invention relates to a fermentation medium for cultivating Corynebacterium diphtheriae. The medium is free from animal-derived components and comprises water, a nitrogen source, a carbon source and an iron supplement, wherein the culture of Corynebacterium diphtheriae in at least 100 L of fermentation medium yields at least 140 Lf/ml of diphtheria toxin. The exemplified source of nitrogen is yeast extract, and the exemplified carbon sourceis maltose. The invention also relates to the use of the fermentation medium in processes for obtaining diphtheria toxin from the Colynebacterium diphtheriae bacteria being cultivated and the preparation of vaccines using the diphtheria toxin obtained in the processes. The present invention further relates to a purification and detoxification processes specifically adapted for preparing a diphtheria toxoid for inclusion into a vaccine. |
| priorityDate |
2011-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |