| abstract |
The present invention relates to compounds capable of binding to the active site of protein kinase enzymes. The invention further relates to libraries of compounds and a family of libraries of compounds for use in screening programmes against protein kinases as well as the individual compounds for use in hit to lead and lead optimisation projects, and similar stages in the drug discovery process. The invention also provides methods for making compounds and libraries. Compounds disclosed are based on a pyrazine, pyridine or fused pyrazine-imidazole core chemical structure or scaffold. The compounds may be useful in the treatment of cancer, tumours, metastases, inflammation or diabetes. |